Purine nucleosides
Chem-Impex International, Inc. N2-Isobutyryl-2'-deoxyguanosine | 68892-42-2 | MFCD00010060 | 5G
N2-Isobutyryl-2'-deoxyguanosine, 68892-42-2, MFCD00010060, 5G
Medchemexpress LLC 2'-Deoxyadenosine monohydrate | 16373-93-6 | 99.9% | 269.26 | 10 G
2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release and glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation. It activates caspase-3 and promotes apoptosis, and inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). This compound can inhibit the growth of various cells and has an anticancer effect on colon cancer.
- Inhibits glucose-stimulated insulin release
- Activates caspase-3 and promotes apoptosis
- Inhibits S-adenosyl-L-homocysteine hydrolase (SAHH) activity
- Inhibits the growth of various cells
- Demonstrates an anticancer effect on colon cancer
- For research use only
Medchemexpress LLC 2'-Deoxyguanosine | 961-07-9 | MFCD00006540 | >=98% | 268.22 | 1 ML
2'-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. It can induce DNA division in mouse thymus cells and is a potent cell division inhibitor in plant cells.
- Purine nucleoside
- Induces DNA division in mouse thymus cells
- Potent cell division inhibitor in plant cells
- Inhibits clonal growth of HL-60 and K562 leukemia cells
Medchemexpress LLC 2'-deoxyadenosine-5'-monophosphate | 653-63-4 | 99.2% | 331.22 | C10H14N5O6P | 25 MG
2'-Deoxyadenosine-5'-monophosphate (dAMP) is a deoxyribonucleotide used as an analytical standard and reference material for nucleic acid research, method validation, and chromatographic or mass-spectrometry assays. Supplied as a solid in amber glass packaging, it is intended for calibration, quantitation, and analytical method development.
- High purity analytical standard suitable for HPLC and MS.
- Purity confirmed by HPLC (99.15% reported by COA).
- Molecular formula C10H14N5O6P and molecular weight 331.22.
- Supplied in brown glass to protect from light and moisture.
- Intended for calibration, method validation, and quantitative analyses.
eMolecules 8-Bromo-2'-deoxyadenosine | 14985-44-5 | | 1g
Combi-Blocks | 8-Bromo-2'-deoxyadenosine | 1g | 457917203 | QB-6653 | 95.000 | 14985-44-5 | | 330.142 | C10H12BrN5O3
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Medchemexpress LLC 2'-deoxyadenosine-5'-monophosphate | 653-63-4 | 99.2% | 331.22 g/mol | C10H14N5O6P | 250 MG
2'-Deoxyadenosine-5'-monophosphate is a deoxyribonucleotide (adenosine monophosphate derivative) provided as a high-purity analytical standard for research and analytical applications, including studies of DNA synthesis and nucleoside metabolism. Supplied as a solid standard in laboratory quantities for use in biochemical assays.
Medchemexpress LLC 6-Thio-2'-Deoxyguanosine | 789-61-7 | 99.7% | 283.31 | 100 MG
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. It causes rapid cell death in most tested cancer cell lines and decreases tumor growth rate in mouse xenograft models, increasing telomere dysfunction in tumor cells in vivo.
- Nucleoside analogue
- Can be incorporated into de novo-synthesized telomeres by telomerase
- Induces rapid cell death in cancer cell lines
- Decreases tumor growth rate in mouse xenograft models
- Increases telomere dysfunction in tumor cells in vivo
- DNA/RNA synthesis inhibitor
Medchemexpress LLC 6-Thio-2'-Deoxyguanosine | 789-61-7 | 99.7% | 283.31 | 10 MM * 1 ML
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase.
- Nucleoside analogue
- Can be incorporated into de novo-synthesized telomeres by telomerase
- Rapid cell death for the vast majority of cancer cell lines tested with IC50s of between 0.7-2.9 μM (in vitro)
- Causes a decrease of the tumor growth rate in A549 lung cancer cell-based mouse xenograft studies, superior to that observed with 6-thioguanine treatment (in vivo)
- Increases telomere dysfunction in tumor cells in vivo
- Appearance: Solid
- Color: White to yellow
Medchemexpress LLC 2'-Deoxyguanosine | 961-07-9 | 267.25 | 1 G
2'-Deoxyguanosine is a purine nucleoside with a variety of biological activities. It can induce DNA division in mouse thymus cells and is a potent cell division inhibitor in plant cells. In vitro, it inhibits the clonal growth of HL-60 and K562 leukemia cells with IC50 values of 50 and 80 μM, respectively.
- Classified as an endogenous metabolite related to cancer
- Analytical standard intended for research and analytical applications (for standard version HY-17563R)
Medchemexpress LLC 2'-Deoxyguanosine | 961-07-9 | >99.9% | 267.25 | 5 G
2'-Deoxyguanosine is a purine nucleoside with diverse biological activities. It can induce DNA division in mouse thymus cells and acts as a potent cell division inhibitor in plant cells. It inhibits the clonal growth of HL-60 and K562 leukemia cells with IC50 values of 50 and 80 μM, respectively. This product is intended for research use only.
- Induces DNA division in mouse thymus cells.
- Acts as a potent cell division inhibitor in plant cells.
- Inhibits clonal growth of HL-60 and K562 leukemia cells.
- Intended for research applications.
Medchemexpress LLC 2'-Deoxyguanosine monohydrate | 312693-72-4 | 99.7% | 5 G
2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and 2'-deoxyribose, and it is one of the basic structural units of DNA.
- The oxidation products may participate in DNA damage.
- May affect gene expression or induce cancer.
Biotium MUC1 / CA15-3 / EMA / CD227 (Epithelial Marker)(VU-4H5), CF740 conjugate, 0.1mg/mL
MAb VU-4H5 reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The dominant epitope of MAb VU4H5 is APDTR as established with 'epitope fingerprinting'. VU-4H5 preferentially binds to under-glycosylated 'tumor' MUC1. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is upregulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.